US Senator John Cornyn, the senior senator representing Texas, announced his campaign for reelection on March 26, 2025. .johncornyn.com
Texas Attorney General Ken Paxton announced his campaign to challenge Senator Cornyn on April 8, 2025. This will create a vacancy in the Office of the Attorney General. kenpaxton.com
Terry Virts, Former US Astronaut and Fighter Pilot, announced his campaign for the Democratic nomination to the Senate seat.
Colin Allred, former US Congressman, announced that he would be running again for the seat.